1 Endometriosis Mohammad

Endometriosis is classically defined as the growth of endometrial glands and stroma at extra-uterine sites, most commonly implanted over visceral and peritoneal surfaces within the female pelvis (1). Though endometriosis has been described for the first time in 1690 by the German physician, Daniel Shroen, researchers remain still unsure as to the definitive cause of this disease (2). The most widely accepted theory for the pathogenesis of endometriosis (retrograde menstruation/transplantation), proposed in the 1927 by Sampson (3). Although a great deal has been learned about endometriosis since Sampson’s land mark studies, there is still a lot about it that is unclear and controversial. It remains an enigmatic disorder in that the cause, the natural history, and the precise mechanisms of its presentation are not known (4).